Viatris has a presence in multiple neurological conditions with a recognised unmet medical need, such as: epilepsy, neuropathic pain (NeP), and migraine.

About Epilepsy

Epilepsy is one of the most common neurological diseases globally¹. It was recognised in 45.9 million people in 2016 and over 126,000 deaths attributed to the condition².

Nearly 80% of people with epilepsy live in low-and-middle-income countries. Three-quarters don't get treatment as needed and up to 70% of people with epilepsy could live seizure-free if properly diagnosed and treated.

About Neuropathic Pain (NeP)

Neuropathic pain is caused by a lesion or disease of the somatosensory system, including peripheral fibres (Aβ, Aδ and C fibres) and central neurons. Multiple causes of neuropathic pain have been described and ³ its incidence and prevalence is likely to increase owing to the ageing global population and the rise in specific risk factors, including diabetes⁴.

NeP places a considerable burden on patients and society with:^5-9

• Substantial impairment in function and quality of life
• Disability
• Work impairment
• Increased healthcare utilization

A. About Painful Diabetic Neuropathic Pain (DPN):
Painful DPN is a common, debilitating complication of diabetes that significantly impacts patients' lives.¹²

Painful diabetic neuropathic pain is characterized by nerve damage, and is also commonly accompanied by oxidative stress, inflammation and mitochondrial dysfunction.¹³

• Neuropathy is one of the most prevalent long-term complications of diabetes ¹⁴ about 50% of all patients with diabetes develop DPN.^15,16
• Painful DPN is one of the most common forms of neuropathic pain, affecting 20% to 24% of the diabetic population.¹⁷
• Pain associated with DPN substantially impacts many aspects of patients' lives, including physical and emotional functioning, walking ability, sleep, anxiety symptoms, and enjoyment of life.¹²
• The total number of people with diabetes is projected to rise from 171 million in 2000 to 366 million in 2030.¹⁸ Peripheral neuropathy affects 30-50% of patients with diabetes.¹⁹

B. Chronic Low Back Pain with an identified Neuropathic Component

Chronic low back pain is the second most common reason for visits to the physician in the United States.²⁰ Approximately 20% of individuals between ages 20-59 experience chronic low back pain.²¹

Back pain can be a combination of both nociceptive and neuropathic components (mixed pain).²²

• 37% of cases of chronic low back pain have a neuropathic component.²³
• NSAIDs are appropriate to address the nociceptive component only.²⁴

• Low back pain with leg pain is strongly associated with reduced health-related quality of life and function.²⁵

  

About Migraine

Migraine is currently listed as being in the top 10 most disabling disorders worldwide in terms of disability adjusted life years.²⁶

Migraine is the most prevalent condition affecting over 1.04 billion people in 2016 worldwide with an estimated 45.1 million years lived with disability (YLD) for the same time period.²⁶

Women are roughly 3x more likely to experience migraine compared with men.²⁷